Perform PC-SAFT predictions inhouse with SOLCALC
The user-friendly Solcalc environment allows a fast and easy integration into your workflows.
Bring your formulation development to the next level – its all within Excel!
Key functions of SOLCALC
- calculation of phase equilibria with PC-SAFT (vapor pressures, solubilities, liquid-liquid-demixing, vapor sorption, phase equilibria at constant humidity). Learn more about PC-SAFT here.
- PC-SAFT database for commonly used excipients, pharmaceuticals, solvents, ions and polymers (approximately 300 pure components, 1800 binary interaction parameters)
- Parameter fitting of pure-component parameters to vapor pressure, density, solubility, vapor sorption data
- Parameter sensitivity analysis tool (e.g. via Monte-Carlo Simulations) and comparison of different parameter sets
- Prediction of glass transitions of amorphous materials and molecular mobility above and below glass transitions
- Unique shelf-life tool to predict the crystallization onset time of metastable ASDs
- Customized calculation tool to predict metastable states, supersaturation or thermodynamic driving forces via activities of multi-component mixtures, octanol/water partitioning or create individual calculation procedures
- 64bit or 32 bit Excel plugin with extensive Excel interoperability (e.g. Excel solver integration)
- Requirement: PC (Windows 10) with Microsoft Excel.
Large parameter database
Modeling of diverse complex processes possible (e.g. spray drying, co-precipitation, scCO2-based processes, … ) due to broad database with most commonly used pharmaceutical excipients. The database contains essential chemicals like solvents, gases, ions, excipients (polymers, sugars, amino acids, surfactants) and model APIs.
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Pure-component parameters
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Binary interaction parameters
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Excipient grades
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Solvents
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Ions
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model APIs
The database is constantly updated with amofors latest parameter developments.