...combining few key experiments with in-silico predictions to find the best formulation for your active ingredient
Key experiments
Only few experiments with small quantities of the expensive active ingredient are required to characterize molecule-specific interactions with other compounds.
Predict long-term stability
The physical stability of amorphous formulations against crystallization and amorphous phase separation is predicted with this innovative quality-by-design approach.
Results of long-term stability tests enduring years are obtained within days.
In-silico calculations
Advanced in-silico modeling tools taking into account the specific intermolecular interactions reveal the optimal formulation and production process windows.
Designing production processes
Identify optimal solvents, solvent mixtures, processing temperatures, drying conditions (spray drying/ coating) for the formulation are assesible without any further screenings.
Your benefit
Identify the best excipients for your formulation
Determine the design space of the production process
Reduce material consumption of expensive active ingredients
Save time – get the results of long-term stability tests even before conducting them
Decrease the number of screening experiments
Understand the influence of critical quality attributes on formulation stability
Using scientific modeling strategies from early formulation development to production
We support
Formulation developers
Solid state characterization
Quality managers: Batch-to-batch consistency. Predict the sensitivity of process variances (e.g. temperature, concentrations fluctuations, excipient quality …)
Process designers: Spray drying/ Crystallization/Hot melt extrusion design
Life cycle managers: Improve an existing formulation
Our partners
We are curious about your challenges in formulation development. Contact us now: