How do you find the right polymer and processing conditions for hot-melt extrusion when you have less than 1 gram
From Phase Diagrams to Hot-Melt Extrusion: A New Workflow for ASD Development Read More »
Case studies, Products
Why does an API remain amorphous during storage, yet fail to release as expected during dissolution? These questions share a
Most drug candidates entering development are poorly soluble, which limits their bioavailability. Over the past few decades, several formulation techniques
Predicting pH-Dependent Solubility, Solid Form, and Polymer Release with PC-SAFT Read More »
Case studies, Science
The glass transition (Tg) line is key to understanding and designing ASDs. In ASD phase diagrams, it is shown alongside
The Glass Transition Line: The Kinetic Lock in Your ASD Phase Diagram Read More »
Insights, Science
Spray drying is the leading method for producing amorphous solid dispersions (ASDs). It is also the process in which many
Spray Drying ASDs: The Formulator’s Question Playbook Read More »
Products, Science
A spray-dried inhalation particle is a few microns wide. It has to carry an amorphous API to the lungs, survive
Almost every amorphous solid dispersion (ASD) is a metastable system: a drug in a polymer matrix in a high‑energy amorphous
ASD Phase Diagrams: The Root of Every Drug Formulation Project Read More »
Products, Science
If you work in drug formulation, you know this problem: a formulation looks fine on paper, but a small change
How Real-World Drug Formulation Challenges Shape amofor’s Internal Research Roadmap Read More »
Insights
SOLCALC helps formulators build a predictive digital twin of their drug formulation. Thus, decisions like polymer or solvent choice can
Product Update: Big Data Fitting Is Now Built into SOLCALC Read More »
Products, Solcalc
For decades, spray drying has relied on a small set of “gold-standard” solvents. If you wanted high solubility, fast evaporation,
In Silico Screening of Greener, Non-Toxic Solvent Systems for Spray Drying of ASDs Read More »
Products, Science