SOLCALC Training: Turning Complex Physical Modeling Into Actionable Insights

How can formulation scientists make more thoughtful decisions without becoming thermodynamics experts? That’s the question that led to SOLCALC.

SOLCALC is an Excel-based add-in designed specifically for drug formulation applications. With the proper training, this software transforms PC-SAFT modeling from a powerful theory into a formulation tool that scientists can use confidently.

Below, we explain how our training works and why it’s as important as the model itself.

Why SOLCALC Training Matters

SOLCALC enables formulators to accurately calculate solubility, phase behavior, stability, and spray drying parameters. But like any powerful tool, it delivers value only when your team understands how to use it.

The software utilizes PC-SAFT (Perturbed Chain Statistical Associating Fluid Theory), one of the most advanced thermodynamic models for predicting the behavior of complex fluids. It tracks how molecules interact based on size, polarity, and hydrogen bonding. Further extensions of the tool account for crystallization kinetics, water uptake, and solvent evaporation, adding important layers of complexity.

With just a few focused sessions, formulators generate insights they can trust and apply effectively.

Choose the SOLCALC Training That Matches Your Needs

We have designed the SOLCALC training program to fit different levels of scientific expertise, project timelines, and formulation goals. Alongside the live sessions, we provide supporting materials – slides and documentation – so your team can revisit key concepts anytime. Depending on how deep you want to go, we offer three training formats:

Basic Training – Setup and Application (1 Day)

Included with every first-year license, basic training gets your team up and running fast. We guide you through:

Navigate the Excel interface
Perform PC-SAFT parameter fitting using your data or published examples
Generate and interpret phase diagrams
Reproduce published models

Within a day, your team can begin running simulations and applying SOLCALC to early formulation tasks such as polymer screening or defining target drug loads.

Intermediate Training – Deeper Understanding (Multi-Day)

For teams working in preclinical or clinical development, intermediate training covers:

How model parameters affect predictions
Shelf life simulation, water uptake, and molecular mobility
Using the model for spray drying and ASD formulation challenges

This format helps teams build scalable formulations and optimize for development-stage manufacturing.

Advanced Training – Scientific Ownership (Biweekly Sessions)

We offer structured biweekly sessions with advanced training for teams looking to fully integrate the model. These sessions include:

Understanding the theory behind PC-SAFT and its sub-models
Custom fitting for novel excipients or APIs
Strategic interpretation for late-stage formulation or regulatory submission

This package is structured as a collaborative program. Each session builds towards full autonomy, where your team can defend model results in regulatory discussions and scientific reviews.

What Kind of Training Data is Required?

The software requires only five solubility measurements in organic solvents, which is far less data than is needed for AI/ML tools. The reason: SOLCALC’s strength lies in its physical foundation. It models intermolecular interactions directly, delivering robust predictions with minimal input.

What Makes Our SOLCALC Training Different

Our team leads every SOLCALC training session – that means the scientists who developed the model, wrote the code, and validated the science behind it. You work directly with the experts who know where the model performs best and where careful interpretation is required.

Our sessions are interactive and tailored to your pipeline. While we can demonstrate the software using well-characterized model compounds, most teams prefer to train on their own API–polymer–solvent systems. This approach brings two key advantages:

Immediate feedback: We evaluate model fit live, make adjustments, and explore what the results mean for your ongoing studies.
Faster impact: Your scientists directly apply what they’ve learned to active formulation projects.

But the real differentiator is the science behind the model itself.

Behind the user-friendly interface runs a system of submodels solving complex sets of equations. This level of detail goes far beyond typical modeling tools. Our training helps your team unlock this depth, turning complex outputs into clear, defendable formulation decisions.

Who Chooses Which SOLCALC Training Package

The software is designed explicitly for formulation scientists, pharmacists, and chemical engineers. We’ve trained scientists from CDMOs and multinational pharmaceutical companies. While the problems may be similar, the time and depth required are different:

CDMOs and smaller teams typically choose Basic or Intermediate Training for fast, effective implementation in early-stage formulation and risk assessment.
Larger pharmaceutical groups often select Advanced Training to support late-stage development, when understanding the model’s inner workings becomes essential.

The Impact of SOLCALC in Real Projects

SOLCALC already supports multiple formulation projects that have reached the filing stage. Teams have used the model to justify:

Polymer selection strategies
Shelf life projections
Spray drying process conditions

Especially for shelf life prediction, SOLCALC helps replace assumptions with data-backed estimates. The model applies physical principles to show how long a formulation will remain stable. This gives formulators a solid foundation for internal decisions and regulatory submissions.

SOLCALC is a digital twin, not just a platform.

Training is what makes it work.

We operate at the intersection of thermodynamic modeling and pharmaceutical formulation. While thermodynamic experts often stay in theory, and pharmacists focus on practical formulation, we bridge that gap. We apply advanced modeling directly to the problems that matter most to formulation scientists – even when those scientists aren’t familiar with the underlying physical chemistry.

This connecting point is where SOLCALC delivers its most substantial value: real answers backed by science and made usable through expert training.

If this is the support your team needs, we’re ready to help you.