Case studies

Polymer screenings

Scientifically sound formulation decisions are possible: determine the best stabilizing polymer for your individual amorphous solid dispersion.

01

Key data

Characterize molecule with few measurements in the lab (e.g. solubility in organic solvents)

02

Model training

Adjust physical model parameters to understand net intermolecular interactions of the molecule

03

Interaction screening

Rank order polymers according to their individual interactions with the drug and release behavior

At a glance

amofor applies a conservative, mechanistic approach to ASD polymer selection. Using PC‑SAFT‑based intermolecular interaction predictions, we produce full in‑silico rankings that do not require additional experiments. When desired, we confirm results using time‑honoured laboratory methods.

  • Decision basis: Intermolecular interactions & miscibility (PC‑SAFT).
  • Scope: All commonly available polymeric excipients for ASDs can be considered.
  • Philosophy: Prefer proven polymers first; validate pragmatically.

Typical ASD Polymers available

Examples considered during screening:

  • PVP (e.g., K30), PVPVA64
  • HPMCAS (L/M/H), HPMC
  • HPMCP‑HP55
  • Eudragit EPO, Eudragit L100, Eudragit L100-55
  • Apinovex
  • Soluplus
  • PEG grades
  • PVA

All ASD-relevant polymers available, also grades of different suppliers!

Ranking Examples

The obtained rankings below are full in‑silico predictions and do not require additional experiments.

Itraconazole ASD
  1. HPMCAS
  2. HPMC‑E5
  3. HPMCP‑HP55
Ritonavir ASD
  1. PVP
  2. PVPVA64
  3. PEG
Piroxicam ASD
  1. PVP
  2. PVPVA64
  3. PEG

Note: The best stabilizing polymer differs from API to API. All potentially available polymeric excipients for ASD generation can be considered in the screening.

Validation & Extensions

Validation Measurements

  • XRPD & DSC checks for amorphousness and recrystallization risk
  • DVS for humidity sensitivity where relevant
  • Basic dissolution ranking (as needed)

Additional Screening

  • Drug‑loading risk assessment across top polymers
  • Release‑mechanism probes for the selected ASD
  • Process hooks (solvent evaporation, melt processing)
Discuss your API